D4 Dopamine Receptors and the Molecular Mechanism of Attention
نویسندگان
چکیده
منابع مشابه
Dopamine D4 receptors: curiouser and curiouser.
Identification of the D, receptor The D4 receptor was fit identified, using molecular biological techniques, from human’ and from rat2 and shown to be a member of the family of G protein-coupled dopamine receptors. It has substantial homology with Dz and DJ receptors (and is a member of the D,-like receptor subfamily) but its distribution and pharmacological properties are different from either...
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Cognitive deficits in individuals with schizophrenia (SCZ) are considered core symptoms of this disorder, and can manifest at the prodromal stage. Antipsychotics ameliorate positive symptoms but only modestly improve cognitive symptoms. The lack of treatments that improve cognitive abilities currently represents a major obstacle in developing more effective therapeutic strategies for this debil...
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پژوهش حاضر با هدف بررسی اثر جیره حاوی کربوهیدراتهای غیرالیافی زیاد و بروز التهاب در گاوهای شیرده در دو آزمایش جداگانه انجام شد. در آزمایش اول 20 رأس گاو مبتلا به ورم پستان از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) و 20 رأس گاو سالم از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) انتخاب شدند. همه گاوها در دوره دوم و یا سوم شیردهی و در روزهای 80-120 پس از زایش بودند. میانگین تولید شیر در گروه...
Norepinephrine activates dopamine D4 receptors in the rat lateral habenula.
The lateral habenula (LHb) is involved in reward and aversion and is reciprocally connected with dopamine (DA)-containing brain regions, including the ventral tegmental area (VTA). We used a multidisciplinary approach to examine the properties of DA afferents to the LHb in the rat. We find that >90% of VTA tyrosine hydroxylase (TH) neurons projecting to the LHb lack vesicular monoamine transpor...
متن کاملHomeostatic regulation of glutamatergic transmission by dopamine D4 receptors.
Alterations of synaptic transmission have been considered a core feature of mental disorders; thus, we examined the role of dopamine D(4) receptors, which is highly implicated in attention-deficit hyperactivity disorder and schizophrenia, in regulating synaptic functions of prefrontal cortex, a brain region critical for cognitive and emotional processes. We found that D(4) stimulation caused a ...
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ژورنال
عنوان ژورنال: CNS Drug Reviews
سال: 2006
ISSN: 1080-563X
DOI: 10.1111/j.1527-3458.2000.tb00163.x